The ability to express a gene of interest in a spatio-temporal manner using Gal4-UAS system has allowed the use of Drosophila model to study various biological phenomenon.During Drosophila eye development, a synchronous wave of differentiation called Morphogenetic furrow (MF) initiates at the posterior margin resulting in differentiation of retinal
Tumor tissues contain both tumor and non-tumor cells, which include infiltrated immune cells and CHAKRA INCENSE ANAHATA WIND stromal cells, collectively called the tumor microenvironment (TME).Single-cell RNA sequencing (scRNAseq) enables the examination of heterogeneity of tumor cells and TME.In this review, we examined scRNAseq datasets for multi
Abstract In the adult vertebrate intestine, multi-potent stem cells continuously generate all of the epithelial cells throughout the adulthood.While it has long been known that the frog intestine is formed via the development of adult intestinal stem cells during thyroid hormone (TH)-dependent metamorphosis, the basic structure of the adult intesti
Background Chimeric antigen receptor T cell (CAR-T)-based immunotherapies have reshaped the therapeutic landscape of cancer treatment, in particular for patients afflicted with leukemia.However, defects in CAR behaviors and clinical complications have hindered their widespread application across diverse cancer types.Chief among these defects is hig
Pranay Dey,1,2 Maitreyi Rathod,1,2 Abhijit De1,2 1Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India; 2Molecular Functional Imaging Lab, Homi Bhabha National Institute, Mumbai, India Abstract: Since its first documentation, breast cancer (BC) has been a conundr